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Chlorogenic Acid and Its Metabolite M-Coumaric Acid Evoke Neurite Outgrowth in Hippocampal Neuronal Cells

Hideyuki Ito, Xiu-Lan Sun, Makiko Watanabe, Motoi Okamoto, Tsutomu Hatano

Biosci Biotechnol Biochem. 2008 Mar;72(3):885-8.

PMID: 18323641

Abstract:

We evaluated the neurotrophic activity of dietary polyphenols by using primary cultures of fetal rat hippocampal neurons in a serum-free medium. Among the tested compounds, chlorogenic acid and its metabolite, m-coumaric acid, together with catechins and flavanone, were found to promote neuronal differentiation comparable to the phytochemical, honokiol, which has been reported to show potent neurotrophic activity. The present findings may contribute to the development of further neurotrophic studies on dietary polyphenols and their metabolites.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP588307 m-Coumaric acid m-Coumaric acid 588-30-7 Price
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