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Cholinergic Medications

Cholinergic Medications

Ramya S. Pakala, Kristen N. Brown

PMID: 30844190

Abstract:

Cholinergic medications are a category of pharmaceutical agents that act upon the neurotransmitter acetylcholine, the primary neurotransmitter within the parasympathetic nervous system (PNS). There are two broad categories of cholinergic drugs: direct-acting and indirect-acting. The direct-acting cholinergic agonists work by directly binding to and activating the muscarinic receptors. Examples of direct-acting cholinergic agents include choline esters (acetylcholine, methacholine, carbachol, bethanechol, tacrine) and alkaloids (muscarine, pilocarpine, cevimeline). Indirect-acting cholinergic agents increase the availability of acetylcholine at the cholinergic receptors. These include reversible agents (physostigmine, neostigmine, pyridostigmine, edrophonium, rivastigmine, donepezil, galantamine) and irreversible agents (echothiophate, parathion, malathion, diazinon, tabun, sarin, soman, carbaryl, propoxur). The use of cholinergic agonists has limitations because of their tendency to cause adverse effects in any organ under the control of the parasympathetic nervous system. Some indications for use are listed below:

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
CS353695	Propoxur-(isopropoxy-d7)			Price

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