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Chromatographic Separation and Spectroscopic Characterization of the E/Z Isomers of Acrivastine

Chromatographic Separation and Spectroscopic Characterization of the E/Z Isomers of Acrivastine

Prakash M Davadra, Batuk Dabhi, Manoj K Singh, Mukul R Jain, Hitendra S Joshi, Atul H Bapodra

Chirality. 2011 Nov;23(10):955-60.

PMID: 21953883

Abstract:

A reverse phase high performance liquid chromatography (HPLC) method has been developed for the separation of two geometric isomers of Acrivastine using crude reaction mixture. The resolution between two isomers was found more than 2.9. The geometric isomers have been isolated by preparative HPLC and characterized by spectroscopic techniques, such as NMR, infrared, and MS. The developed method has been validated for the determination of Z-isomer in Acrivastine. The limit of detection and limit of quantification of the Z-isomer were 0.05 and 0.2 μg/ml, respectively. The developed method is precise, linear, accurate, rugged and robust for its intended use.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP51657911	Triprolidine hydrochloride Z-Isomer		51657-91-1	Price

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