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Chromium-Catalyzed Regioselective Kumada Arylative Cross-Coupling of C(aryl)-O Bonds With a Traceless Activation Strategy

Chromium-Catalyzed Regioselective Kumada Arylative Cross-Coupling of C(aryl)-O Bonds With a Traceless Activation Strategy

Fei Fan, Jinghua Tang, Meiming Luo, Xiaoming Zeng

J Org Chem. 2018 Nov 2;83(21):13549-13559.

PMID: 30284826

Abstract:

We report here the chromium-catalyzed regioselective Kumada arylative cross-coupling of C(aryl)-O bonds at ambient temperature. By using a simple and low-cost chromium(II) chloride salt as a precatalyst, accompanied by a 2-pyridyl ligation, the catalytic cleavage and arylative coupling of C(aryl)-O bonds were achieved with a traceless activation strategy, overcoming the regioselectivity obstacle when several C-O bonds coexist in the Kumada coupling system.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP10049055	Chromium(II) chloride		10049-05-5	Price

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