Chromosomal Assignment of the Human Gene Encoding the Fos-related antigen-2 (FRA2) to Chromosome 2p22-p23

Home
Resources
Publications
Chromosomal Assignment of the Human Gene Encoding the Fos-related antigen-2 (FRA2) to Chromosome 2p22-p23

Chromosomal Assignment of the Human Gene Encoding the Fos-related antigen-2 (FRA2) to Chromosome 2p22-p23

A Molven, G Houge, R Berger

Genomics. 1996 Nov 15;38(1):72-5.

PMID: 8954781

Abstract:

The four members of the Fos gene family give rise to proteins that are part of the AP-1 transcription factor complex. When studying cAMP-induced apoptosis in a leukemia cell line from rat, we found that the Fra-2 gene (coding for the Fos-related antigen-2) became strongly upregulated as the leukemia cells started to die. It was therefore of interest to determine the cytogenetic localization of the human Fra-2 gene (FRA2), including a comparison to chromosomal aberrations observed in leukemia patients. Based on sequence information from the rat and chicken Fra-2 homologs, we were able to PCR-amplify a 4.5-kb genomic fragment covering exon 4 of FRA2. This fragment was employed as probe for both radioactive and fluorescence in situ hybridization to human metaphase chromosomes, allowing us to assign FRA2 to 2p22-p23. The localization of the gene to chromosome 2 was independently verified by PCR amplification of a FRA2-specific fragment from a panel of rodent-human somatic cell hybrids.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42414970	Fos-related antigen 1 human			Price

As a specialist in analytical chemical products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: