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Chrysophanol: A Review of Its Pharmacology, Toxicity and Pharmacokinetics

Chrysophanol: A Review of Its Pharmacology, Toxicity and Pharmacokinetics

Long Xie, Hailong Tang, Jiawen Song, Jiaying Long, Linlin Zhang, Xiaofang Li

J Pharm Pharmacol. 2019 Oct;71(10):1475-1487.

PMID: 31373015

Abstract:

Objective:
Chrysophanol is a natural anthraquinone, also known as chrysophanic acid and 1,8-dihydroxy-3-methyl-anthraquinone. It has been widely used in the food and pharmaceutical fields. This review is intended to provide a comprehensive overview of the pharmacology, toxicity and pharmacokinetic researches of chrysophanol.
Key finding:
Information on chrysophanol was collected from the Internet database PubMed, Elsevier, ResearchGate, Web of Science, Wiley Online Library and Europe PM using a combination of keywords including 'pharmacology', 'toxicology' and 'pharmacokinetics'. The literature we collected included from January 2010 to June 2019. Chrysophanol has a wide spectrum of pharmacological effects, including anticancer, antioxidation, neuroprotection, antibacterial and antiviral, and regulating blood lipids. However, chrysophanol has obvious hepatotoxicity and nephrotoxicity, and pharmacokinetics indicate that the use of chrysophanol in combination with other drugs can reduce toxicity and enhance efficacy.
Summary:
Chrysophanol can be used in many diseases. Future research directions include how the concentration of chrysophanol affects pharmacological effects and toxicity; the mechanism of synergy between chrysophanol and other drugs.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP481743	Chrysophanol		481-74-3	Price

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