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Chrysophanol, an Anthraquinone From AST2017-01, Possesses the Anti-Proliferative Effect Through Increasing p53 Protein Levels in Human Mast Cells

Chrysophanol, an Anthraquinone From AST2017-01, Possesses the Anti-Proliferative Effect Through Increasing p53 Protein Levels in Human Mast Cells

Na-Ra Han, Hee-Yun Kim, Soonsik Kang, Mi Hye Kim, Kyoung Wan Yoon, Phil-Dong Moon, Hyung-Min Kim, Hyun-Ja Jeong

Inflamm Res. 2019 Jul;68(7):569-579.

PMID: 31055607

Abstract:

Objective:
Natural products are well known as the source of drugs in the treatment of allergic inflammation. Chrysophanol, an anthraquinone from the AST2017-01 extract, showed a beneficial anti-inflammatory effect on activated human mast cells in our previous study. However, a regulatory effect of AST2017-01 and chrysophanol on mast cell proliferation induced by thymic stromal lymphopoietin (TSLP) remains unclear. The present study determined the anti-proliferative effect and the fundamental mechanism of AST2017-01 and chrysophanol in mast cells.
Methods:
We evaluated an anti-proliferative effect of AST2017-01 and chrysophanol in TSLP-stimulated human mast cell line, HMC-1.
Results:
Without cytotoxicity, AST2017-01 and chrysophanol decreased mast cells growth and Ki67 mRNA expression increased by TSLP. AST2017-01 and chrysophanol enhanced expressions of p53 and Bax, whereas inhibited expression of Bcl-2. AST2017-01 and chrysophanol restored caspase-3 activity which was decreased by TSLP. AST2017-01 and chrysophanol suppressed expressions of murine double minute-2 protein and phosphorylated-signal transducer and activator of transcription six which are associated with the regulation of p53 protein. AST2017-01 and chrysophanol decreased levels of interleukin (IL)-13, IL-6, and tumor necrosis factor-α. Moreover, AST2017-01 and chrysophanol reduced mRNA expressions of TSLP receptor and IL-7 receptor α.
Conclusions:
Therefore, this study proposes that AST2017-01 and chrysophanol may be promising candidates for the development of potent anti-inflammatory or health functional foods.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP481743	Chrysophanol		481-74-3	Price

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