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Cigarette Smoking by Baboons: In Vivo Assessment of Particulate Inhalation Using Bronchoalveolar Lavage to Recover [14C]dotriacontane

Cigarette Smoking by Baboons: In Vivo Assessment of Particulate Inhalation Using Bronchoalveolar Lavage to Recover [14C]dotriacontane

W R Rogers, B McCullough, J E Caton

Toxicology. 1981;20(4):309-21.

PMID: 7314121

Abstract:

In order to demonstrate quantitatively that cigarette-smoking baboons inhale particulate matter into the lung, a bronchoalveolar lavage method for recovery of [14C]dotriacontane was developed. First, 9 baboons were exposed to a known dose of [14C]dotriacontane labeled particulate matter delivered in a manner providing extensive deposition of particulates in the lung. The lungs of these passively exposed animals then were lavaged so that the efficiency of recovery of the standardized lavage procedure could be determined. Second, 9 baboons actively smoked labeled cigarettes, and the lungs of these animals were lavaged to recover labeled [14C]dotriacontane. The total amount of particulate matter present in the lungs was estimated using the efficiency factor previously determined. The smoking baboons retained an average of 9% of he total cigarette particulate matter. Differences among animals in retention of particulate matter were considerable, and the inter-animal variability was related to differences in number, volume, duration, and pressure of puffs. The retention of particulate matter by baboons is similar to particulate retention by other animal smoke inhalation models.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP544854	Dotriacontane		544-85-4	Price

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