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Cinnamycin (Ro 09-0198) Promotes Cell Binding and Toxicity by Inducing Transbilayer Lipid Movement

Cinnamycin (Ro 09-0198) Promotes Cell Binding and Toxicity by Inducing Transbilayer Lipid Movement

Asami Makino, Takeshi Baba, Kazushi Fujimoto, Kunihiko Iwamoto, Yoshiaki Yano, Nobuo Terada, Shinichi Ohno, Satoshi B Sato, Akinori Ohta, Masato Umeda, Katsumi Matsuzaki, Toshihide Kobayashi

J Biol Chem. 2003 Jan 31;278(5):3204-9.

PMID: 12446685

Abstract:

Cinnamycin is a unique toxin in that its receptor, phosphatidylethanolamine (PE), resides in the inner layer of the plasma membrane. Little is known about how the toxin recognizes PE and causes cytotoxicity. We showed that cinnamycin induced transbilayer phospholipid movement in target cells that leads to the exposure of inner leaflet PE to the toxin. Model membrane studies revealed that cinnamycin induced transbilayer lipid movement in a PE concentration-dependent manner. Re-orientation of phospholipids was accompanied by an increase in the incidence of beta-sheet structure in cinnamycin. When the surface concentration of PE was high, cinnamycin induced membrane re-organization such as membrane fusion and the alteration of membrane gross morphology. These results suggest that cinnamycin promotes its own binding to the cell and causes toxicity by inducing transbilayer lipid movement.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP110655588	Cinnamycin		110655-58-8	Price

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