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Circulating Transforming Growth factor-β1 Facilitates Remyelination in the Adult Central Nervous System

Circulating Transforming Growth factor-β1 Facilitates Remyelination in the Adult Central Nervous System

Machika Hamaguchi, Rieko Muramatsu, Harutoshi Fujimura, Hideki Mochizuki, Hirotoshi Kataoka, Toshihide Yamashita

Elife. 2019 May 9;8:e41869.

PMID: 31071011

Abstract:

Oligodendrocyte maturation is necessary for functional regeneration in the CNS; however, the mechanisms by which the systemic environment regulates oligodendrocyte maturation is unclear. We found that Transforming growth factor (TGF)-β1, which is present in higher levels in the systemic environment, promotes oligodendrocyte maturation. Oligodendrocyte maturation was enhanced by adult mouse serum treatment via TGF-β type I receptor. Decrease in circulating TGF-β1 level prevented remyelination in the spinal cord after toxin-induced demyelination. TGF-β1 administration promoted remyelination and restored neurological function in a multiple sclerosis animal model. Furthermore, TGF-β1 treatment stimulated human oligodendrocyte maturation. These data provide the therapeutic possibility of TGF-β for demyelinating diseases.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248691	Transforming Growth Factor-β1 human			Price

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