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Cirsilineol Inhibits Proliferation of Cancer Cells by Inducing Apoptosis via Mitochondrial Pathway

Cirsilineol Inhibits Proliferation of Cancer Cells by Inducing Apoptosis via Mitochondrial Pathway

Xia Sheng, Yang Sun, Ye Yin, Ting Chen, Qiang Xu

J Pharm Pharmacol. 2008 Nov;60(11):1523-9.

PMID: 18957174

Abstract:

Cirsilineol (4',5-dihydroxy-3',6,7-trimethoxyflavone) is a compound isolated from the herb of Artemisia vestita Wall (Compositae). In this study, we aimed at examining the anti-proliferative activity of cirsilineol against multiple types of cancer cells and the underlying mechanisms. Cirsilineol significantly inhibited proliferation of Caov-3, Skov-3, PC3 and Hela cells in a concentration-dependent manner. The compound also dose-dependently induced apoptosis in Caov-3 cells, as determined by annexin V/propidium iodide staining. Besides, cirsilineol induced a remarkable change in mitochondrial membrane potential and caused release of cytochrome c to cytosol. Furthermore, the compound caused a marked activation of capase-3, caspase-9 and poly (ADP-ribose) polymerase (PARP). These results suggested that the induction of apoptosis via the mitochondrial pathway was involved in the anti-proliferative activity of cirsilineol against cancer cells.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP41365326	Cirsilineol		41365-32-6	Price

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