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Cisplatin-incorporated Nanoparticles of Poly(acrylic Acid-Co-Methyl Methacrylate) Copolymer

Cisplatin-incorporated Nanoparticles of Poly(acrylic Acid-Co-Methyl Methacrylate) Copolymer

Kyung Dong Lee, Young-Il Jeong, Da Hye Kim, Gyun-Taek Lim, Ki-Choon Choi

Int J Nanomedicine. 2013;8:2835-45.

PMID: 23966778

Abstract:

Background:
Although cisplatin is extensively used in the clinical field, its intrinsic toxicity limits its clinical use. We investigated nanoparticle formations of poly(acrylic acid-co-methyl methacrylate) (PAA-MMA) incorporating cisplatin and their antitumor activity in vitro and in vivo.
Methods:
Cisplatin-incorporated nanoparticles were prepared through the ion-complex formation between acrylic acid and cisplatin. The anticancer activity of cisplatin-incorporated nanoparticles was assessed with CT26 colorectal carcinoma cells.
Results:
Cisplatin-incorporated nanoparticles have small particle sizes of less than 200 nm with spherical shapes. Drug content was increased according to the increase of the feeding amount of cisplatin and acrylic acid content in the copolymer. The higher acrylic acid content in the copolymer induced increase of particle size and decrease of zeta potential. Cisplatin-incorporated nanoparticles showed a similar growth-inhibitory effect against CT26 tumor cells in vitro. However, cisplatin-incorporated nanoparticles showed improved antitumor activity against an animal tumor xenograft model.
Conclusion:
We suggest that PAA-MMA nanoparticles incorporating cisplatin are promising carriers for an antitumor drug-delivery system.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP24979713	Poly(4-vinylphenol-co-methyl methacrylate)		24979-71-3	Price

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