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Clinical Application of 11-deoxycortisol in Visualizing Prolapsed Vitreous Body After Posterior Capsule Rupture in Cataract Surgery

Clinical Application of 11-deoxycortisol in Visualizing Prolapsed Vitreous Body After Posterior Capsule Rupture in Cataract Surgery

Yuichi Kaji, Takahiro Hiraoka, Fumiki Okamoto, Masaki Sato, Tetsuro Oshika

J Cataract Refract Surg. 2005 Jun;31(6):1133-8.

PMID: 16039486

Abstract:

Purpose:
To evaluate the clinical usefulness of 11-deoxycortisol, a precursor of cortisol in steroid metabolism, in visualizing the vitreous body in the anterior chamber after posterior capsule rupture during cataract surgery.
Setting:
Department of Ophthalmology, Tsukuba University Hospital, Ibaraki, Japan.
Methods:
Eight eyes had anterior vitrectomy during cataract surgery using this new technique. A suspension of 11-deoxycortisol was prepared by dilution in balanced salt solution without preservatives or emulsifying agents. After a posterior capsule rupture, the suspension was injected into the anterior chamber. The visual and anatomical outcomes of surgery were evaluated during a follow-up of 7 to 9 months.
Results:
After the 11-deoxycortisol injection, the vitreous body that had prolapsed through the torn posterior capsule, with white particles entrapped on its surface, became clearly visible. Complete removal of the prolapsed vitreous body was achieved easily and safely using an anterior vitrectomy system. No postoperative complications related to the use of 11-deoxycortisol were observed.
Conclusion:
Injection of 11-deoxycortisol helped visualize the vitreous body in the anterior chamber after posterior capsule rupture. The technique minimized intraoperative and postoperative complications related to posterior capsule rupture and vitreous loss during cataract surgery [corrected]

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP152589	11-Deoxycortisol solution		152-58-9	Price

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