Home
Resources
Publications
Clinical Effectiveness of Submucosal Injection With Indigo Carmine Mixed Solution for Colon Endoscopic Mucosal Resection

Clinical Effectiveness of Submucosal Injection With Indigo Carmine Mixed Solution for Colon Endoscopic Mucosal Resection

Su Jung Han, Yunho Jung, Young Sin Cho, Il-Kwun Chung, Jae Yun Kim, Jun Young Eun, Seoung Ho Lee, Gyu Bong Ko, Tae Hoon Lee, Sang Hum Park, Hyun Deuk Cho, Sun-Joo Kim

Dig Dis Sci. 2018 Mar;63(3):775-780.

PMID: 29383606

Abstract:

Background/aims:
Submucosal injection with indigo carmine mixed solution can improve the delineation of colorectal neoplasia during endoscopic mucosal resection (EMR). Thus, the aim of this study was to evaluate the efficacy of submucosal injection with indigo carmine mixed solution during EMR of colorectal neoplasia.
Methods:
This was a prospective, randomized, controlled study of a total of 212 neoplastic colon polyps (5-20 mm) subjected to EMR in a single tertiary university hospital. The patients were randomized into two groups according to whether or not indigo carmine mixed solution was used, and the complete resection rate (CRR) after EMR was evaluated.
Results:
A total of 212 neoplastic polyps (normal saline group, 115; indigo carmine group, 97) were successfully removed by EMR. There was no significant difference in the CRR (92.8 vs. 89.6%, p = 0.414) or macroscopic delineation (86.0 vs. 93.8%, p = 0.118) between the two groups. In a separate analysis of sessile serrated adenomas/polyps (SSAs/Ps), macroscopic delineation was better in the indigo carmine group than the normal saline group (87.5 vs. 53.8%), albeit not significantly (p = 0.103). In univariate analyses, the CRR was significantly related to polyp location, polyp morphology, macroscopic delineation, and pathologic findings. In a multiple logistic regression analysis, macroscopic delineation (odds ratio (OR), 7.616, p = 0.001) and polyp pathology (OR, 8.621; p < 0.001) were significantly associated with the CRR.
Conclusions:
Submucosal injection with indigo carmine mixed solution did not improve the CRR or macroscopic delineation of EMR of colorectal neoplasias.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP860220-A	Indigo carmine		860-22-0	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: