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Clinical Evaluation of Sustained-Release Metronidazole Gel Versus Metronidazole Solution as an Intracanal Medicament in Abscessed Primary Molars

Clinical Evaluation of Sustained-Release Metronidazole Gel Versus Metronidazole Solution as an Intracanal Medicament in Abscessed Primary Molars

M B Bhangdia, B Nandlal, G S Vijaykumar, P K Kulkarni, R Shanbhog

Eur Arch Paediatr Dent. 2014 Feb;15(1):19-26.

PMID: 23754205

Abstract:

Aim:
To evaluate the efficacy of metronidazole gel versus metronidazole solution against Enterococcus faecalis in abscessed primary molars.
Study design:
A clinical trial.
Method:
Twenty pulpally involved non-vital carious human primary mandibular second molars with furcal abscess were randomly allocated into two groups to evaluate the efficacy of metronidazole gel (3% w/v) and metronidazole solution (0.5% w/v) against E. faecalis. Subjects in the first experimental group were subjected to treatment with metronidazole gel (3% w/v) and subjects in the second experimental group were treated with metronidazole solution (0.5% w/v). Two microbial samples (pre-operative and post-operative samples) were obtained from the root canals of each subject from both the groups; sub cultured and efficacy of both the groups were evaluated.
Results:
Overall percentage reduction of the mean colony forming unit (CFU) count of metronidazole gel (3% w/v) group was 96.39% and metronidazole solution (0.5 % w/v) was 90.90%. Results of intergroup t test of the percentage difference of mean CFU counts between both the groups revealed a statistically highly significant difference, i.e. p value--0.008 (p < 0.01).
Conclusions:
Metronidazole gel (3% w/v) was more effective than metronidazole solution (0.5% w/v) against E. faecalis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP443481-A	Metronidazole solution		443-48-1	Price

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