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Clinical, Histologic, and Bacteriologic Findings in Dairy Cows With Digital Dermatitis (Footwarts) One Month After Topical Treatment With Lincomycin Hydrochloride or Oxytetracycline Hydrochloride

Clinical, Histologic, and Bacteriologic Findings in Dairy Cows With Digital Dermatitis (Footwarts) One Month After Topical Treatment With Lincomycin Hydrochloride or Oxytetracycline Hydrochloride

Steven L Berry, Deryck H Read, Richard L Walker, Thomas R Famula

J Am Vet Med Assoc. 2010 Sep 1;237(5):555-60.

PMID: 20807134

Abstract:

Objective:
To compare the effectiveness of lincomycin and oxytetracycline for treatment of digital dermatitis (DD) in dairy cows through gross visual examination, histologic evaluation, and bacteriologic evaluation.
Design:
Randomized controlled clinical trial.
Animals:
25 cows with DD lesions from a commercial Holstein dairy herd.
Procedures:
Cows with DD lesions were randomly assigned to 1 of 3 groups: topical treatment with 10 g of lincomycin hydrochloride (n = 11), topical treatment with 10 g of oxytetracycline hydrochloride (11), and no treatment (3) on days 1 and 2 (d1). Biopsy specimens were obtained for histologic examination from DD lesions prior to treatment and 28 or 31 days (d30) after treatment for histologic examination. Cows were clinically examined on d1, days 12 or 14 (d14), and d30.
Results:
No difference was evident in clinical responses to lincomycin and oxytetracycline, so data were pooled; at d30, 8 of 11 of lincomycin-treated lesions and 7 of 11 oxytetracycline-treated lesions appeared visually healed, respectively. Gross visual examination suggested 73% (16/22) of treated cows were healed at d14 and 68% (15/22) of treated cows were healed on d30. Of the 15 lesions that appeared healed on d30, 7 of 15 were classified histologically as active (ulceration and bacterial invasion; 2/15) or incipient (5/15).
Conclusions and clinical relevance:
Clinical responses to lincomycin and oxytetracycline did not differ. Agreement was good between gross visual and histologic assessments of DD lesions before treatment; agreement 1 month after treatment was variable. Histologic evaluation could not distinguish incomplete healing from lesion recurrence.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP7179499-B	Lincomycin Hydrochloride		7179-49-9	Price

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