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Clinical Value of Magnetic Resonance Imaging in Patients With Mayer-Rokitansky-Küster-Hauser (MRKH) Syndrome: Diagnosis of Associated Malformations, Uterine Rudiments and Intrauterine Endometrium

Clinical Value of Magnetic Resonance Imaging in Patients With Mayer-Rokitansky-Küster-Hauser (MRKH) Syndrome: Diagnosis of Associated Malformations, Uterine Rudiments and Intrauterine Endometrium

H Preibsch, K Rall, B M Wietek, S Y Brucker, A Staebler, C D Claussen, K C Siegmann-Luz

Eur Radiol. 2014 Jul;24(7):1621-7.

PMID: 24737529

Abstract:

Objectives:
The aim of this study was to evaluate the accuracy of preoperative magnetic resonance imaging (MRI) in the diagnosis of malformations associated with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome and identification of uterine endometrium to optimise the clinical management.
Methods:
We retrospectively reviewed 214 consecutive MRKH patients, mean age 19 years, who underwent laparoscopy-assisted neovagina creation. A total of 115 patients (53.7%) met the inclusion criterion of sufficient preoperative MRI. In 110 of them (95.7%), MRI findings were correlated with laparoscopy and associated malformations. In 39 cases (35.5%) uterine rudiments were removed and analysed histopathologically.
Results:
Ten per cent (11/110) of the patients showed complete uterine agenesis. The others presented with either unilateral (n = 16; 14.5%) or bilateral (n = 83; 75.5%) uterine rudiments. MRI detection of uterine rudiments agreed in 78.2% (86/110) with laparoscopy. In 85.4% of the removed rudiments, MRI could correctly diagnose the existence of the endometrium. Compared to laparoscopy, MRI could exactly detect ovaries in 97.3% (107/110). Renal or ureteral malformations were seen in 32 cases (27.8%). In 83% of unilateral renal agenesis and unilateral rudiment, the latter was located at the side of the kidney.
Conclusions:
MRI is useful for preoperative detection of MRKH-associated malformations and assessment of the endometrium to further optimise MRKH patient treatment.
Key points:
• Pelvic MRI is useful for preoperative detection of MRKH-associated malformations. • MRI can diagnose uterine endometrium in MRKH patients with high precision. • Preoperative MRI can optimise clinical management of patients with MRKH syndrome.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP179388659	AH 11110		179388-65-9	Price

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