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Cloning and Expression Profile of Mouse and Human Genes, Rnf11/RNF11, Encoding a Novel RING-H2 Finger Protein

Cloning and Expression Profile of Mouse and Human Genes, Rnf11/RNF11, Encoding a Novel RING-H2 Finger Protein

N Seki, A Hattori, A Hayashi, S Kozuma, M Sasaki, Y Suzuki, S Sugano, M A Muramatsu, T Saito

Biochim Biophys Acta. 1999 Dec 23;1489(2-3):421-7.

PMID: 10673045

Abstract:

The RING finger (C3HC4-type zinc finger) is a variant zinc finger motif presents in a new family of proteins. A new member of the RING finger family was identified and its cDNA structures were determined in human and mouse. The predicted protein consisting of a 144 amino acid residues is very conservative between the two species and contains a canonical RING-H2 finger motif (C3H2C2) at the carboxyl-terminal region. The genes were designated as RNF11/Rnf11 for RING finger protein 11. A single 2.4-kb transcript of mouse Rnf11 was ubiquitously expressed in various fetal and adult mouse tissues by the Northern blot analysis. The human RNF11 gene was mapped on chromosome 1p31-p32 region, where frequent alterations have been observed in T-cell acute lymphoblastic leukemia.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42415038	RNF11 human			Price

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