Home
Resources
Publications
[CME: Ethylene Glycol Intoxication]

[CME: Ethylene Glycol Intoxication]

Sandra Ringler, Roman Gmuer, Katrin Faber, Jörg Bleisch, Simon Andreas Müggler

Praxis (Bern 1994). 2018;107(20):1097-1106.

PMID: 30278847

Abstract:

CME: Ethylene Glycol Intoxication Abstract. Ethylene glycol is a sweet-tasting alcohol used in common antifreeze and other industrial solutions. Without appropriate therapy, intoxication with ethylene glycol can result in severe metabolic acidosis, acute renal failure, and in death. After gastrointestinal resorption, hepatic metabolism starts with oxidation by alcohol dehydrogenase and results in severe anion gap metabolic acidosis. Other metabolic products are calcium oxalate crystals, which can deposit in several tissues like the kidneys and lead to acute tubular necrosis with reversible renal failure. The crucial therapeutic step is rapid inhibition of alcohol dehydrogenase with fomepizole or ethanol to avoid the formation of toxic metabolites. Additionally, haemodialysis is the most effective way to eliminate ethylene glycol as well as its toxic metabolites. If therapy is initiated rapidly, prognosis is favorable.

Chemicals Related in the Paper:

Catalog Number	Product Name	CAS Number	Price
AP114740408	O-Methyl-undecaethylene glycol	114740-40-8	Price
AP627861	1,2-Dioctanoylethylene glycol	627-86-1	Price
LS7411294	Polyethylene-block-poly(ethylene glycol)		Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: