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Co-delivery of Drug and DNA From Cationic Dual-Responsive Micelles Derived From poly(DMAEMA-co-PPGMA)

Co-delivery of Drug and DNA From Cationic Dual-Responsive Micelles Derived From poly(DMAEMA-co-PPGMA)

Xian Jun Loh, Shi Jie Ong, Yin Ting Tung, Hoi Teng Choo

Mater Sci Eng C Mater Biol Appl. 2013 Dec 1;33(8):4545-50.

PMID: 24094158

Abstract:

The synthesis and gene transfection efficiency of a series of amphiphilic copolymers with poly(dimethylaminoethyl methacrylate) (PDMAEMA), and poly(propylene glycol methacrylate) (PPGMA) segments is reported. The hydrophobic PPGMA interior allows a cell-sensitizing drug such as paclitaxel to be incorporated while the cationic and hydrophilic PDMAEMA corona allows the complexation of anionic DNA to form a nano-sized polyplex. These drug-encapsulated copolymers display excellent gene transfection efficiency as compared to PEI or PDMAEMA homopolymers.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP39420456	Poly(propylene glycol) methacrylate		39420-45-6	Price

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