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Co-delivery of Metformin and Levofloxacin Hydrochloride Using Biodegradable Thermosensitive Hydrogel for the Treatment of Corneal Neovascularization

Co-delivery of Metformin and Levofloxacin Hydrochloride Using Biodegradable Thermosensitive Hydrogel for the Treatment of Corneal Neovascularization

Dong Liu, Qianni Wu, Yuqiong Zhu, Yijun Liu, Xiuli Xie, Sihan Li, Haotian Lin, Weirong Chen, Fangming Zhu

Drug Deliv. 2019 Dec;26(1):522-531.

PMID: 31090470

Abstract:

Corneal neovascularization (CNV) is one of the major causes of severe disorders in ocular surface. Subconjunctival administration provides a localized and effective delivery of anti-angiogenic agents to inhibit neovascularization. In the present study, the ABA triblock copolymer of poly(D,L-lactic-co-glycolic acid)-block-poly(ethylene glycol)-block-poly(D,L-lactic-co-glycolic acid) (PLGA-PEG-PLGA) was used as a sustained drug delivery carrier for metformin (MET) and levofloxacin hydrochloride (LFH). Both drugs and PLGA-PEG-PLGA copolymers could be easily dissolved in water at low or room temperature and the mixed solution could form a drug-loaded thermosensitive hydrogel in terms of body temperature response. The in vitro release investigation displayed a sustained release of MET and LFH from the formulation for one month. The in vivo efficacy of subconjunctival injection of the MET + LFH loaded thermosensitive hydrogel in inhibiting CNV was evaluated on a mouse model of corneal alkali burn. Compared with the single administration of MET or LFH loaded thermosensitive hydrogel, the MET + LFH loaded thermosensitive hydrogel remarkably inhibited the formation of CNV. The sustained release of MET and an antibiotic (LFH) provides synergistic therapeutic outcome. As a result, the co-delivery of MET and LFH using PLGA-PEG-PLGA thermosensitive hydrogel by subconjunctival injection has great potential for ocular anti-angiogenic therapy.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1115704-A	Metformin hydrochloride solution		1115-70-4	Price

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