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Cobalt-Catalyzed Allylation of Heterobicyclic Alkenes: Ligand-Induced Divergent Reactivities

Yuan Huang, Chao Ma, Yi Xin Lee, Rui-Zhi Huang, Yu Zhao

Angew Chem Int Ed Engl. 2015 Nov 9;54(46):13696-700.

PMID: 26384219

Abstract:

The allylation of heterobicyclic alkenes is presented for the first time. By using an inexpensive cobalt salt as the catalyst and easy-to-handle potassium allyltrifluoroborate as the reagent, an unprecedented formal hydroallylation of the bicyclic alkenes is realized in high efficiency. When a chiral cobalt/bis(phosphine) complex is used instead, the alternative ring-opening products can be obtained in high yield and excellent enantioselectivity.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP216434821 Potassium p-tolyltrifluoroborate Potassium p-tolyltrifluoroborate 216434-82-1 Price
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