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Cobalt-Catalyzed Asymmetric Allylation of Cyclic Ketimines

Liang Wu, Qihang Shao, Guoqiang Yang, Wanbin Zhang

Chemistry. 2018 Jan 26;24(6):1241-1245.

PMID: 29120070

Abstract:

A CoII /Box-catalyzed [Box=bis(oxazoline)] enantioselective addition of potassium allyltrifluoroborate to cyclic ketimines was developed, providing the corresponding chiral α-tertiary amines in high yields and with good enantioselectivity values. Alkoxycarbonyl- and alkyl-substituted saccharin-derived ketimines are suitable substrates for this allylation reaction. The product can be converted to complex molecules over several simple steps, including a precursor of MK-0371, which is a kinesin spindle protein inhibitor. In addition, this catalytic system showed a strong positive nonlinear effect.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP216434821 Potassium p-tolyltrifluoroborate Potassium p-tolyltrifluoroborate 216434-82-1 Price
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