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Cobalt-Catalyzed C-H Nitration of Indoles by Employing a Removable Directing Group

Paridhi Saxena, Manmohan Kapur

Chem Asian J. 2018 Apr 4;13(7):861-870.

PMID: 29424476

Abstract:

A mild and efficient C(sp2 )-H nitration of 3-substituted indoles, by using the economical and non-toxic cobalt nitrate hexahydrate [Co(NO3 )2 ⋅6 H2 O] as a catalyst and tert-butyl nitrite (TBN) as the nitro source, is reported. This approach provides a unique methodology involving a site-selective C-N bond formation for preparation of C-2 substituted nitro indoles. Utilization of the tBoc as the removable directing group enhances the synthetic utility of the method.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP10026229 Cobalt(II) nitrate hexahydrate Cobalt(II) nitrate hexahydrate 10026-22-9 Price
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