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Coconut Oil Consumption Improves Fat-Free Mass, Plasma HDL-cholesterol and Insulin Sensitivity in Healthy Men With Normal BMI Compared to Peanut Oil

Coconut Oil Consumption Improves Fat-Free Mass, Plasma HDL-cholesterol and Insulin Sensitivity in Healthy Men With Normal BMI Compared to Peanut Oil

Damayanti Korrapati, Shanmugam Murugaiha Jeyakumar, Uday Kumar Putcha, Vishnuvardhana Rao Mendu, Laxmi Rajkumar Ponday, Vani Acharya, Swarupa Rani Koppala, Ayylasomayajula Vajreswari

Clin Nutr. 2019 Dec;38(6):2889-2899.

PMID: 30630708

Abstract:

Background & aims:
The existing scientific evidence on coconut oil consumption and its health effects remains inconclusive due to varied reasons. In this context, we conducted a well-controlled metabolic study, eliminating some of the confounding factors and assessed the effects of the consumption of coconut oil-based diet on various anthropometric, biochemical and inflammatory markers and compared with peanut oil-diet.
Methods:
Nine healthy male volunteers with BMI ≤25 kg/m2 were enrolled for this study and given balanced diets prepared with coconut oil (CO; ~35 g) for a period of eight weeks. After a wash-out period of six weeks, the same subjects were provided with diets prepared with peanut oil (~35 g) for eight weeks. Except fat source, the composition of the diets was identical in all aspects.
Results:
Compared to basal values, there were significant increases in fat-free mass (p ≤ 0.022), plasma HDL-cholesterol (HDL-C) (p ≤ 0.047) and insulin sensitivity of the subjects at the end of CO-consumption. Further, compared to peanut oil, increase in plasma HDL-C was significant (p = 0.004) in CO treatment. On the other hand, plasma inflammatory markers-associated with cardiovascular diseases (CVD), namely soluble vascular cell adhesion molecule 1 (sVCAM1) and matrix metalloproteinase levels were reduced significantly by CO-intake. Further, these subjects displayed elevated levels of myristic acid (14:0) in plasma phospholipids at the end of CO-consumption, which correlated positively with HDL-C and negatively with sVCAM1. However, no such changes were observed after peanut oil diet consumption.
Conclusions:
In conclusion, compared to peanut oil, the consumption of coconut oil in a balanced diet resulted in increased fat-free mass, plasma HDL-C, elicited favourable changes on insulin sensitivity and CVD risk-associated parameters in healthy men with normal BMI.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP8002037	Peanut oil		8002-03-7	Price

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