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Coenzyme B12 Repurposed for Photoregulation of Gene Expression

Karl Gruber, Bernhard Kräutler

Angew Chem Int Ed Engl. 2016 May 4;55(19):5638-40.

PMID: 27010518

Abstract:

Old cofactor, new tricks: In enzymes, coenzyme B12 has a well-known function as a radical initiator through homolysis of the Co-C bond. It has recently been shown that nature has repurposed this cofactor as a photosensitive switch for the regulation of bacterial carotenoid biosynthesis. Co-C bond breakage is again the key event in this process, triggering huge conformational changes in the B12 -binding protein.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP13870901 Coenzyme B12 Coenzyme B12 13870-90-1 Price
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