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Collagen Stimulating Effect of Peptide Amphiphile C16-KTTKS on Human Fibroblasts

Collagen Stimulating Effect of Peptide Amphiphile C16-KTTKS on Human Fibroblasts

Roanne R Jones, Valeria Castelletto, Che J Connon, Ian W Hamley

Mol Pharm. 2013 Mar 4;10(3):1063-9.

PMID: 23320752

Abstract:

The collagen production of human dermal and corneal fibroblasts in contact with solutions of the peptide amphiphile (PA) C16-KTTKS is investigated and related to its self-assembly into nanotape structures. This PA is used in antiwrinkle cosmeceutical applications (trade name Matrixyl). We prove that C16-KTTKS stimulates collagen production in a concentration-dependent manner close to the critical aggregation concentration determined from pyrene fluorescence spectroscopy. This suggests that self-assembly and the stimulation of collagen production are inter-related.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248426	Collagen Solution from human fibroblasts			Price

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