Home
Resources
Publications
Collagenolytic Cathepsin B and L Activity in Experimental Fibrotic Liver and Human Liver

Collagenolytic Cathepsin B and L Activity in Experimental Fibrotic Liver and Human Liver

H Yamamoto, Y Murawaki, H Kawasaki

Res Commun Chem Pathol Pharmacol. 1992 Apr;76(1):95-112.

PMID: 1518964

Abstract:

To clarify the role of individual collagenolytic cathepsin in hepatic collagen degradation, cathepsin B and L activities were determined in normal and CCl4-induced fibrotic liver, together with non-collagenolytic cathepsin H. Cathepsin B and L activities increased 1.9- and 2.0- fold, respectively, in the fibrotic liver as compared with the normal liver, and were significantly correlated with hepatic hydroxyproline levels. By contrast, cathepsin H activity was not altered in fibrotic rats. Similar results were also obtained from autopsied human livers. These results suggest that cathepsin B and L are similarly induced by hepatic collagen levels and are implicated in degrading collagens, especially soluble collagen.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42412309	Cathepsin L, Human Liver			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: