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Combinatorial Nano-Bio Interfaces

Pingqiang Cai, Xiaoqian Zhang, Ming Wang, Yun-Long Wu, Xiaodong Chen

ACS Nano. 2018 Jun 26;12(6):5078-5084.

PMID: 29883094

Abstract:

Nano-bio interfaces are emerging from the convergence of engineered nanomaterials and biological entities. Despite rapid growth, clinical translation of biomedical nanomaterials is heavily compromised by the lack of comprehensive understanding of biophysicochemical interactions at nano-bio interfaces. In the past decade, a few investigations have adopted a combinatorial approach toward decoding nano-bio interfaces. Combinatorial nano-bio interfaces comprise the design of nanocombinatorial libraries and high-throughput bioevaluation. In this Perspective, we address challenges in combinatorial nano-bio interfaces and call for multiparametric nanocombinatorics (composition, morphology, mechanics, surface chemistry), multiscale bioevaluation (biomolecules, organelles, cells, tissues/organs), and the recruitment of computational modeling and artificial intelligence. Leveraging combinatorial nano-bio interfaces will shed light on precision nanomedicine and its potential applications.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP667463629-A BIO BIO 667463-62-9 Price
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