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Comedogenicity in Rabbit: Some Cosmetic ingredients/vehicles

Comedogenicity in Rabbit: Some Cosmetic ingredients/vehicles

Shawn H Nguyen, Thao P Dang, Howard I Maibach

Cutan Ocul Toxicol. 2007;26(4):287-92.

PMID: 18058303

Abstract:

The rabbit external ear canal was used to define which chemicals caused comedone formation on topical application. Some of the tested ingredients are currently used in topically applied formulations. Certain raw materials have been shown to produce follicular hyperkeratosis in the rabbit ear assay. This study quantifies comedogenic potential of cosmetic materials, including: isopropyl palmitate, isopropyl myristate, butyl stearate, isopropyl isostearate, decyl oleate, isostearyl neopentanoate, isocetyl stearate, myristle myristate, cocoa butter, cetyl alcohol, paraffin, stearyl alcohol sodium lauryl sulfate (SLS), and petrolatum. The first nine were deemed positive. Factors aiding clinical relevance are listed.

Chemicals Related in the Paper:

Catalog Number	Product Name	CAS Number	Price
AP112925-A	Stearyl Alcohol	112-92-5	Price
AP123955-A	Butyl stearate	123-95-5	Price
AP142916-1-A	Isopropyl palmitate	142-91-6	Price

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