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Comparative Carcinogenic Potencies of 7H-dibenzo[c,g]carbazole, Dibenz[a,j]acridine and Benzo[a]pyrene in Mouse Skin

Comparative Carcinogenic Potencies of 7H-dibenzo[c,g]carbazole, Dibenz[a,j]acridine and Benzo[a]pyrene in Mouse Skin

D Warshawsky, W Barkley

Cancer Lett. 1987 Nov;37(3):337-44.

PMID: 3677065

Abstract:

The relative carcinogenic potencies of three combustion products of fossil fuels, 7H-dibenzo[c,g]carbazole (7H-DB[c,g]C), dibenz[a,j]acridine (DB[a,j]A) and benzo[a] pyrene (B[a]P) were compared using complete carcinogenicity C3H mouse skin bioassays. Both 7H-DB[c,g]C and B[a]P produced tumors in 48 of 50 mice with latency periods of 36.6 and 32.4 weeks, respectively. DB[a,j]A produced tumors in 25 of 50 mice with a latency period of 80 weeks. 7H-DB[c,g]C was found to be as potent a carcinogen as B[a]P when applied to mouse skin. These results have important implications in the determination of relative carcinogenic potencies of complex mixtures.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP215623	Dibenz[a,c]acridine		215-62-3	Price

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