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Comparative Efficacies of Topical Antiseptic Eardrops Against Biofilms From Methicillin-Resistant Staphylococcus Aureus and Quinolone-Resistant Pseudomonas Aeruginosa

Comparative Efficacies of Topical Antiseptic Eardrops Against Biofilms From Methicillin-Resistant Staphylococcus Aureus and Quinolone-Resistant Pseudomonas Aeruginosa

C K Youn, Y Jun, E-R Jo, S-J Jang, H Song, S I Cho

J Laryngol Otol. 2018 Jun;132(6):519-522.

PMID: 29909794

Abstract:

Objective:
The present study aimed to compare the anti-biofilm activities of four commonly available antiseptic eardrops against biofilms from methicillin-resistant Staphylococcus aureus and quinolone-resistant Pseudomonas aeruginosa in vitro.
Methods:
The anti-biofilm activities of 50 per cent Burow's solution, vinegar with water (1:1), 2 per cent acetic acid solution, and 4 per cent boric acid solution were evaluated using biofilm assays. Additionally, the anti-biofilm activities of the four antiseptic solutions against tympanostomy tube biofilms were compared using a scanning electron microscope.
Results:
The inhibition of biofilm formation from methicillin-resistant S aureus and quinolone-resistant P aeruginosa occurred after treatment with 4 per cent boric acid solution, 2 per cent acetic acid solution, and vinegar with water (1:1). However, 50 per cent Burow's solution did not exhibit effective anti-biofilm activity.
Conclusion:
The results indicate that 4 per cent boric acid solution and vinegar with water (1:1) are potent inhibitors of biofilms from methicillin-resistant S aureus and quinolone-resistant P aeruginosa, and provide safe pH levels for avoiding ototoxicity.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42410417	Glycodeoxycholic-2,2,4,4,11,11-d6 acid solution			Price

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