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[Comparative Evaluation of Methacycline Hydrochloride Capsules and Tablets According to Their Dissolubility and Rate of Solution]

[Comparative Evaluation of Methacycline Hydrochloride Capsules and Tablets According to Their Dissolubility and Rate of Solution]

L N Berezovskaia, L K Grakovskaia, L Ia Nesterova

Antibiotiki. 1979 Aug;24(8):604-8.

PMID: 485108

Abstract:

Desintegration and dissolution of capsules and tablets of methacycline hydrochloride were studied. The study on solubility of methacycline hydrochliride capsules filled with methacycline granulate or powder according to the same formula showed that the rate of the antibiotic liberation from the capsules filled with the powder decreased during storage while that from the capsules filled with the granulate did not change. Investigation of the effect of the mass packing value in a drop on the antibiotic liberation from the capsules showed that an increase in the packing coefficient above 1.38 resulted in a marked decrease in the rate of methacycline liberation from the capsules filled with the granulate. No correlation between desintegration and dissolution of methacycline capsules and tablets was found.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP3963959-B	Methacycline hydrochloride		3963-95-9	Price

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