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Comparative Lethality of In Ovo Exposure to PCB 126, PCB 77, and 2 Environmentally Relevant PCB Mixtures in Japanese Quail (Coturnix Japonica)

Comparative Lethality of In Ovo Exposure to PCB 126, PCB 77, and 2 Environmentally Relevant PCB Mixtures in Japanese Quail (Coturnix Japonica)

Karen M Dean, Allegra M Marcell, Leah D Baltos, Tiffany Carro, Meredith E B Bohannon, Mary Ann Ottinger

Environ Toxicol Chem. 2019 Dec;38(12):2637-2650.

PMID: 31436847

Abstract:

The Japanese quail (Coturnix japonica) egg bioassay was used to directly compare the toxicity of 3,3',4,4',5-pentachlorobiphenyl (PCB 126), 3,3',4,4'-tetrachlorobiphenyl (PCB 77), and 2 environmentally relevant polychlorinated biphenyl (PCB) mixtures over specified dose ranges relative to vehicle and uninjected controls. Measures included lethality and deformities. Results showed clear dose-response relationships for PCB 126 and the 2 PCB mixtures by logistic analysis of covariance using a varying threshold model because there was a low but significant slope for mortality of vehicle controls over incubation. No dose-dependent increase in mortality was observed with PCB 77 treatment. Mortality increased above baseline for PCB 126 and the 2 mixtures after embryonic day 7 (ED07) to a stable slope from ED10. Median lethal doses and thresholds for response differed for PCB 126 and the 2 PCB mixtures, with the mixtures having lower initial toxicity and all showing progressively greater toxicity over the course of development. Further, the lethality of the PCB mixtures appeared to involve both aryl hydrocarbon receptor (AhR) and non-AhR mechanisms. Incidence of deformities was unrelated to treatments. In summary, complex mixtures of PCBs were lethal in a dose-related manner, with sublethal effects from exposure to PCB 77. Environ Toxicol Chem 2019;38:2637-2650. © 2019 SETAC.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP33284503	PCB No 7		33284-50-3	Price

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