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Comparative Mitogenic Response of Old and Young Rhesus Monkey T Cells to Lectin From Erythrina Cristagalli

Comparative Mitogenic Response of Old and Young Rhesus Monkey T Cells to Lectin From Erythrina Cristagalli

E H Eylar, F Molina, C Quiñones, M Zapata, M Kessler

Immunol Lett. 1989 Jul;22(1):13-6.

PMID: 2789182

Abstract:

The lectin (EC) from the coral tree, E. cristagalli, while less mitogenic on a molar or weight basis than PHA or ConA, strongly activates both Rhesus monkey and human T cells. The optimal mitogenic concentrations for both Rhesus and human T cells are 0.25, 2.5, and 25 micrograms/ml, respectively, for PHA, ConA, and EC. Aged Rhesus T cells were profoundly suppressed in mitogenic response to EC (approx. 80%) compared to young Rhesus cells. However, in the presence of supplemental interleukin 2 (20 U/ml), the age-related defect was reversed; the average mitogenic response of the old Rhesus T cells was increased sixfold.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42417963	Lectin from Erythrina cristagalli (coral tree)			Price

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