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Comparative Pharmacokinetics of Swertiamarin in Rats After Oral Administration of Swertiamarin Alone, Qing Ye Dan Tablets and Co-Administration of Swertiamarin and Oleanolic Acid

Comparative Pharmacokinetics of Swertiamarin in Rats After Oral Administration of Swertiamarin Alone, Qing Ye Dan Tablets and Co-Administration of Swertiamarin and Oleanolic Acid

Gui-li Xu, Hong-liang Li, Jian-chang He, En-fu Feng, Pan-pan Shi, Yue-qiong Liu, Chang-xiao Liu

J Ethnopharmacol. 2013 Aug 26;149(1):49-54.

PMID: 23791808

Abstract:

Ethnopharmacological relevance:
Qing Ye Dan is a well-known herbal drug that is widely used to treat viral hepatitis in the Yi and Hani minority regions in the Yunnan province of China.
Materials and methods:
An LC-MS/MS method was developed to determine the levels of swertiamarin in rat plasma. Swertiamarin and naringin (internal standard, IS) were extracted from rat plasma using solid-phase extraction (SPE) to purify the samples. The pharmacokinetics of the following different administration methods of swertiamarin in rats were studied: oral administration of swertiamarin alone, a Qing Ye Dan tablet (QYDT) and co-administration of swertiamarin and oleanolic acid, with each method delivering approximately 20mg/kg of swertiamarin. Non-compartmental pharmacokinetic profiles were constructed by using the software DAS (version 2.1.1), and the pharmacokinetic parameters were compared using an unpaired Student's t-test.
Results:
The results showed that the pharmacokinetic parameters Cmax, AUC0-∞, Vz/F and CLz/F were significantly different (P<0.05) among the three types of swertiamarin administration.
Conclusions:
The data indicate that oleanolic acid and the other ingredients present in QYDT could affect the pharmacokinetic behaviour of swertiamarin in rats.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP17388395-A	Swertiamarin		17388-39-5	Price

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