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Comparative Study of the Constitution and Chiroptical Properties of Emissive Terbium and Europium Complexes With a Common Tetraazatriphenylene Sensitiser; The Nature of the Sensitiser Determines Quenching Sensitivity and Cellular Uptake

Comparative Study of the Constitution and Chiroptical Properties of Emissive Terbium and Europium Complexes With a Common Tetraazatriphenylene Sensitiser; The Nature of the Sensitiser Determines Quenching Sensitivity and Cellular Uptake

Elizabeth J New, David Parker, Robert D Peacock

Dalton Trans. 2009 Jan 28;(4):672-9.

PMID: 19378560

Abstract:

Six pairs of Eu(III) and Tb(III) complexes of macrocyclic ligands, incorporating a common tetraazatriphenylene sensitiser, have been examined in terms of their solution structure, sensitivity to excited state quenching, protein affinity, cell toxicity and preliminary cell localisation profiles. A complex with three (S)-phenylalanine-derived ligating groups possesses distinctive 1H NMR, Eu emission and circularly polarised emission properties, consistent with a unique A-configuration in the 9-coordinate complex, where an amide carbonyl group occupies the capping position of the coordination polyhedron. Each complex possesses similar sensitivity to quenching by ascorbate, urate and iodide, has similar toxicity behaviour and shows a common intracellular localisation profile that is consistent with compartmentalisation in lysosomes or late endosomes. Such behaviour accords with the hypothesis that it is the nature of the sensitising moiety that determines each of these properties.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP13813406	Terbium(III) iodide		13813-40-6	Price

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