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Comparative Study of Tinidazole Versus Metronidazole in Treatment of Amebic Liver Abscess: A Randomized Control Trial

Comparative Study of Tinidazole Versus Metronidazole in Treatment of Amebic Liver Abscess: A Randomized Control Trial

Sudhakar Pandey, Gaurav Kumar Gupta, Shashank J Wanjari, Sandeep Nijhawan

Indian J Gastroenterol. 2018 May;37(3):196-201.

PMID: 29948994

Abstract:

Background:
Metronidazole is a drug of choice for amebic liver abscess (ALA), but has long course and significant side effects. Thus, drugs like tinidazole with a better tolerability record need evaluation.
Methods:
We conducted a randomized controlled trial at the Department of Gastroenterology, SMS Hospital, Jaipur, India. One hundred and fifty admitted patients were randomized into two treatment groups, metronidazole (group M, n = 75) and tinidazole (group T, n = 75). Patients were observed for clinical response, laboratory parameters, imaging, and side effects. Early clinical response (ECR) was defined as the absence of fever and abdominal pain within 72 h of treatment. Symptomatic clinical response (SCR) was defined as the absence of fever and abdominal pain irrespective of duration of treatment required. Follow up was done at 1, 3, and 6 months.
Results:
ECR was 62.3% in group T vs. 37.7% in group M (p = 0.02). SCR was shorter in group T than group M (3.29 ± 1.61 days vs. 5.67 ± 2.93, p ≤ 0.001). Mean residual volume at the end of 1 month was lower in group T (130.7 ± 108.1 vs. 184.7 ± 143.3 mL, p = 0.01) and no significant difference was seen at 3 and 6 months. Tinidazole was better tolerated with fewer side effects. Low socioeconomic status, baseline abscess volume > 500 mL, hypoalbuminemia, pleural effusion, and history of ethanol use were associated with a late clinical response on univariate analysis of which low socioeconomic status was the only associated factor.
Conclusion:
Tinidazole, as compared to metronidazole, has early clinical response, shorter treatment course, favorable rate of recovery, and high tolerability; thus, tinidazole can be preferred over metronidazole in ALA.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP19387918-A	Tinidazole		19387-91-8	Price

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