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Comparison of Esomeprazole Enteric-Coated Capsules vs Esomeprazole Magnesium in the Treatment of Active Duodenal Ulcer: A Randomized, Double-Blind, Controlled Study

Comparison of Esomeprazole Enteric-Coated Capsules vs Esomeprazole Magnesium in the Treatment of Active Duodenal Ulcer: A Randomized, Double-Blind, Controlled Study

Xiao-Yan Liang, Qing Gao, Neng-Ping Gong, Li-Ping Tang, Pi-Long Wang, Xiao-Hong Tao

World J Gastroenterol. 2008 Mar 28;14(12):1941-5.

PMID: 18350637

Abstract:

Aim:
To evaluate the efficacy and tolerability of two different preparations of esomeprazole in healing duodenal ulcers.
Methods:
A total of 60 patients with active duodenal ulcers were enrolled and randomized to receive esomeprazole enteric-coated capsules (40 mg) or esomeprazole magnesium (40 mg), once daily, for 4 consecutive wk, with ulcer healing being monitored by endoscopy. Safety and tolerability were also assessed.
Results:
Fifty seven patients completed the whole trial. The ulcer healing rates at the end of wk 2 were 86.7% and 85.2% in the esomeprazole enteric-coated capsules and esomeprazole magnesium groups, respectively (P = 0.8410), and reached 100% at the end of wk 4 in both groups. Symptom relief at the end of wk 2 was 90.8% in the esomeprazole enteric-coated capsules group and 86.7% in the esomeprazole magnesium group (P = 0.5406); at the end of wk 4 symptom relief was 95.2% and 93.2%, respectively (P = 0.5786). Adverse events occurred in 16.7% of the esomeprazole enteric-coated capsules group and 14.8% of the esomeprazole magnesium group (P = 1.0000).
Conclusion:
The efficacies of esomeprazole enteric-coated capsules and esomeprazole magnesium in healing duodenal ulcer lesions and relieving gastrointestinal symptoms are equivalent. The tolerability and safety of both drugs were comparable.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP217087097	Esomeprazole Magnesium		217087-09-7	Price

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