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Comparison of High Sensitivity Micro Differential Scanning Calorimetry With X-ray Powder Diffractometry and FTIR Spectroscopy for the Characterization of Pharmaceutically Relevant Non-Crystalline Materials

Comparison of High Sensitivity Micro Differential Scanning Calorimetry With X-ray Powder Diffractometry and FTIR Spectroscopy for the Characterization of Pharmaceutically Relevant Non-Crystalline Materials

M Song, W Liebenberg, M M De Villiers

Pharmazie. 2006 Apr;61(4):336-40.

PMID: 16649550

Abstract:

In this study, high sensitivity micro differential scanning calorimetry (MDSC) in the scanning of dynamic mode was compared to X-ray powder diffractometry (XRPD) for quantifying amorphous nifedipine in mixtures crystalline nifedipine. This technique was also compared with FTIR for quantifying polymorph A of chloramphenicol palmitate (CAP) and poly DL-lactide-co-glycolide) (PLGA) in pharmaceutical formulations. The limit of determination (LOD) achieved by MDSC were 0.06% compared to 5% for XRPD quantification of amorphous nifedipine and 0.02% compared to 7% for IR quanitfication of polymorph A of CAP. As little as 0.165 mg PLGA could be measured in excipients mixtures. Desirable linearity and repeatability were established in all cases.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP530438-C	Chloramphenicol palmitate polymorph A		530-43-8	Price

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