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Comparison of Mineral Trioxide Aggregate and Calcium Hydroxide for Apexification of Immature Permanent Teeth: A Systematic Review and Meta-Analysis

Comparison of Mineral Trioxide Aggregate and Calcium Hydroxide for Apexification of Immature Permanent Teeth: A Systematic Review and Meta-Analysis

Jia-Cheng Lin, Jia-Xuan Lu, Qian Zeng, Wei Zhao, Wen-Qing Li, Jun-Qi Ling

J Formos Med Assoc. 2016 Jul;115(7):523-30.

PMID: 26911724

Abstract:

Background/purpose:
Calcium hydroxide and mineral trioxide aggregate (MTA) are used for inducing a calcific barrier at an open tooth root (apexification). The purpose of this study was to compare the efficacy of calcium hydroxide and MTA for apexification of immature permanent teeth.
Methods:
Medline, Cochrane, EMBASE, and Google Scholar were searched until November 24, 2015, using the keywords apexification, permanent teeth, MTA, and calcium hydroxide.
Results:
Of 216 studies identified, four studies were included. There were no differences in the clinical success rate [pooled odds ratio (OR) = 3.03, 95% confidence interval (CI): 0.42-21.72, p = 0.271], radiographic success rate (pooled OR = 4.30, 95% CI: 0.45-41.36, p = 0.206), or apical barrier formation rate (pooled OR = 1.71, 95% CI: 0.59-4.96, p = 0.322) between calcium hydroxide and MTA groups. The time required for apical barrier formation was significantly less in the MTA group (pooled difference in means = -3.58, 95% CI: from -4.91 to -2.25, p < 0.001).
Conclusion:
While both materials provide similar success rates, the shorter treatment time with MTA may translate into higher overall success rates because of better patient compliance.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1305620-A	Calcium hydroxide		1305-62-0	Price

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