Home
Resources
Publications
Comparison of Pain Response After Subcutaneous Injection of Two Maropitant Formulations to Beagle Dogs

Comparison of Pain Response After Subcutaneous Injection of Two Maropitant Formulations to Beagle Dogs

Nynke Deckers, Catharina A Ruigrok, Hans Peter Verhoeve, Nicky Lourens

Vet Rec Open. 2018 Feb 17;5(1):e000262.

PMID: 29531751

Abstract:

The antiemetic maropitant, with metacresol as preservative (Cerenia, Zoetis), has been associated with pain after subcutaneous injection in dogs and cats. Recently, a generic formulation containing benzyl alcohol was authorised (Prevomax, Le Vet). Benzyl alcohol is reported to have local anaesthetic properties and reduce injection pain. This study compared local pain after subcutaneous injection of the two maropitant formulations, administered at approximately 4°C and 25°C, to dogs. Thirty-two healthy beagle dogs were enrolled into a blinded, randomised, cross-over study. Dogs received subcutaneous injections of maropitant injection containing metacresol as preservative and maropitant injection containing benzyl alcohol as preservative, both at approximately 4°C and 25°C, with at least three days in between treatments. Injection pain was evaluated by two blinded observers using a visual analogue scale immediately after injection and a simple descriptive scale at two minutes after injection. In healthy beagle dogs, subcutaneous injection of maropitant with benzyl alcohol is significantly less painful than injection of maropitant with metacresol.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP912617711	4-(6-Mercaptohexyloxy)benzyl alcohol		912617-71-1	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: