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Comparison of Sedation by Intranasal Dexmedetomidine and Oral Chloral Hydrate for Pediatric Ophthalmic Examination

Comparison of Sedation by Intranasal Dexmedetomidine and Oral Chloral Hydrate for Pediatric Ophthalmic Examination

Qianzhong Cao, Yiquan Lin, Zhubin Xie, Weihua Shen, Ying Chen, Xiaoliang Gan, Yizhi Liu

Paediatr Anaesth. 2017 Jun;27(6):629-636.

PMID: 28414899

Abstract:

Background and aim:
Pediatric ophthalmic examinations can be conducted under sedation either by chloral hydrate or by dexmedetomidine. The objective was to compare the success rates and quality of ophthalmic examination of children sedated by intranasal dexmedetomidine vs oral chloral hydrate.
Methods:
One hundred and forty-one children aged from 3 to 36 months (5-15 kg) scheduled to ophthalmic examinations were randomly sedated by either intranasal dexmedetomidine (2 μg·kg-1 , n = 71) or oral chloral hydrate (80 mg·kg-1 , n = 70). The primary endpoint was successful sedation to complete the examinations including slit-lamp photography, tonometry, anterior segment analysis, and refractive error inspection. The secondary endpoints included quality of eye position, intraocular pressure, onset time, duration of examination, recovery time, discharge time, any side effects during examination, and within 48 h after discharge.
Results:
Sixty-one children were sedated by dexmedetomidine with a success rate of 85.9%, which is significantly higher than that by chloral hydrate (64.3%) [OR 3.39, 95% CI: 1.48-7.76, P = 0.003]. Furthermore, children in the dexmedetomidine group displayed better eye position in anterior segment analysis than in chloral hydrate group median difference. All children displayed stable hemodynamics and none suffered hypoxemia in both groups. Oral chloral hydrate induced higher percentages of vomiting and altered bowel habit after discharge than dexmedetomidine.
Conclusions:
Intranasal dexmedetomidine provides more successful sedation and better quality of ophthalmic examinations than oral chloral hydrate for small children.

Chemicals Related in the Paper:

Catalog Number	Product Name	CAS Number	Price
ALP172617844	CP-64434 hydrate	172617-84-4 (anhydrous)	Price
ALP400856691	AC-41848 hydrate	400856-69-1 (anhydrous)	Price
ALP525596649	bPiDl hydrate	525596-64-9 (anhydrous)	Price

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