Home
Resources
Publications
Comparison of the Effects of Carbamyl-Beta-Methylcholine Chloride Administered by Intravenous, Intramuscular and Intra-Acupuncture Point Injections

Comparison of the Effects of Carbamyl-Beta-Methylcholine Chloride Administered by Intravenous, Intramuscular and Intra-Acupuncture Point Injections

Yu-Min Wang, Jun-Hong Gao, Bo Lu, Juan Peng, Fan Bin, Jing-Jing Cui, Hong-Xin Wang, Yan-Yan Ma, Xiao-Chun Yu

J Tradit Chin Med. 2012 Mar;32(1):93-8.

PMID: 22594110

Abstract:

Objective:
To compare the effects of carbamyl-beta-methylcholine chloride (CMCC) administered by intra-acupuncture point injection (IAI), intramuscular injection (IMI), and intravenous injection (IVI), and to analyze the mechanisms.
Methods:
In the IAI group, CMCC was injected into the Zusanli acupoint (ST 36) immediately after 30-min stimulation by electro-acupuncture (EA) at the acupoints, and into the femoral vein and skeletal muscle in IVI and IMI groups, respectively. Intra-gastric pressure was detected. The plasma concentration of CMCC was measured at various times.
Results:
The gastric effect of CMCC in the IVI group was enhanced and attenuated more rapidly than in the other groups. In the IAI group, this effect was significantly stronger than that in the IMI group at 2 min and 15 min, but not significantly different between the two groups at 5 min and 30 min. Plasma concentration of CMCC in the IAI group was similar to that in the IVI group at 2 min, but higher than that in the IMI group. The concentration in the IAI group was higher than that in the IV group and similar to that in the IMI group at 5, 15 and 30 min, indicating rapid increase and slower reduction of the plasma concentration of the drug in the IAI group. There was a positive correlation between the plasma concentration of CMCC and intragastric pressure in all groups.
Conclusion:
The effect of IAI with CMCC was stronger than that of IMI and longer-lasting than that of IVI, which correlated with the blood concentration of CMCC.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP590636-B	Carbamyl-β-methylcholine chloride		590-63-6	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: