Home
Resources
Publications
Comparison of the Effects of Etomidate and Its Fluoro Analogue, R 8110, on Plasma Cortisol, 11 Beta-Deoxycortisol, 17 Alpha-Hydroxyprogesterone and Testosterone Concentrations in Dogs

Comparison of the Effects of Etomidate and Its Fluoro Analogue, R 8110, on Plasma Cortisol, 11 Beta-Deoxycortisol, 17 Alpha-Hydroxyprogesterone and Testosterone Concentrations in Dogs

R De Coster, A D Degryse, P Van Dijk, L A Ooms, E Lagerweij

J Vet Pharmacol Ther. 1987 Sep;10(3):227-32.

PMID: 3656509

Abstract:

R 8110, an imidazole derivative, was shown to be clinically superior to etomidate for induction and maintenance of anaesthesia in dogs. The present study compared the effects of intravenous (i.v.) R 8110, etomidate and Ringer solution on cortisol biosynthesis by the adrenal gland in seven male labradors. A tetracosactide challenge was carried out 30 min after the i.v. injection of 3 mg/kg of both drugs and after i.v. Ringer solution (1 ml/kg). Etomidate and R 8110 both suppressed the cortisol response to tetracosactide almost completely and increased the plasma 11 beta-deoxycortisol levels more than 20 fold. Maximal 11 beta-deoxycortisol values were reached 120 min after R 8110, and not less than 300 min after etomidate. Plasma 17 alpha-hydroxyprogesterone and testosterone concentrations did not differ between placebo and R 8110 treatment, but they decreased after etomidate. These results indicate that the effects of R 8110 on steroid biosynthesis in dogs are less pronounced than those of etomidate and are largely limited to a temporary inhibition of the 11 beta-hydroxylase in the adrenal gland.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP152589	11-Deoxycortisol solution		152-58-9	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: