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Comparison of the Oral Absorption, Distribution, Excretion, and Bioavailability of Zinc Sulfate, Zinc Gluconate, and Zinc-Enriched Yeast in Rats

Comparison of the Oral Absorption, Distribution, Excretion, and Bioavailability of Zinc Sulfate, Zinc Gluconate, and Zinc-Enriched Yeast in Rats

Shuang-Qing Zhang, Xue-Feng Yu, Hai-Bo Zhang, Ning Peng, Zhi-Xian Chen, Qian Cheng, Xiao-Li Zhang, Sui-Han Cheng, Yan Zhang

Mol Nutr Food Res. 2018 Apr;62(7):e1700981.

PMID: 29457347

Abstract:

Scope:
The oral absorption, distribution, excretion, and bioavailability of zinc sulfate (ZnS), zinc gluconate (ZnG), and zinc-enriched yeast (ZnY) in rats are fully and systemically compared for the first time.
Methods and results:
After zinc compounds were orally administered to rats at a single dose of 4 mg Zn kg-1 , blood, tissues, urine, and feces at different time points were collected for the quantification of zinc concentration. Blood was also harvested for the zinc assay in the multiple-dose administration. Plasma zinc levels among three zinc compounds showed no difference, and zinc was widely distributed in various tissues with the level sequence of bone > liver > pancreas > testes. The net Zn balance was 2.993, 5.125, and 7.482% for ZnS, ZnG, and ZnY, respectively.
Conclusion:
ZnS, ZnG, and ZnY show equivalent bioavailability based on plasma and tissues zinc levels, although ZnY was statistically more absorbed and retained than ZnS and ZnG based on the excretion amount.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP7446200-A	Zinc sulfate		7446-20-0	Price

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