Home
Resources
Publications
Compatibility of Clindamycin Phosphate With Aztreonam in Polypropylene Syringes and With Cefoperazone Sodium, Cefonicid Sodium, and Cefuroxime Sodium in Partial-Fill Glass Bottles

Compatibility of Clindamycin Phosphate With Aztreonam in Polypropylene Syringes and With Cefoperazone Sodium, Cefonicid Sodium, and Cefuroxime Sodium in Partial-Fill Glass Bottles

D A Marble, J A Bosso, R J Townsend

Drug Intell Clin Pharm. 1988 Jan;22(1):54-7.

PMID: 3349921

Abstract:

The stability and compatibility of clindamycin phosphate admixed with four beta-lactams, an experimental monobactam (aztreonam), and three cephalosporins (cefoperazone sodium, cefonicid sodium, and cefuroxime sodium), were studied. Aztreonam alone and the combination of clindamycin phosphate-aztreonam were prepared in duplicate polypropylene syringes. Each cephalosporin antibiotic as well as the three clindamycin phosphate-cephalosporin combinations were admixed in duplicate 100 ml partial-fill glass bottles containing either dextrose 5% in water or NaCl 0.9%. All solutions were examined, antibiotic concentrations were determined, and pH was measured at the time of admixture and 1, 4, 8, 12, 24, and 48 hours later. The solutions were maintained at room temperature under fluorescent lighting for the length of the study. Antibiotic concentrations were determined by drug-specific high performance liquid chromatographic assays. Significant instability or incompatibility was defined as a decrease in concentration of greater than ten percent relative to the initial concentration measured at the time of admixture. All antibiotics were stable for 48 hours. In the combination studies, clindamycin was stable for 48 hours, both in partial-fill glass bottles and syringes. Aztreonam, cefoperazone, cefonicid, and cefuroxime were also stable for 48 hours.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP61270788	Cefonicid sodium		61270-78-8	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: