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Compatibility of Ticagrelor With Pharmaceutical Excipients Studied With Thermal and Spectroscopic Techniques

Jing Zhao, Jinhai Shen, Meiyu Gan, Cuiting Huang, Qihua You

Pharmazie. 2019 Oct 1;74(10):583-589.

PMID: 31685081

Abstract:

The compatibility between ticagrelor and selected excipients (mannitol, calcium phosphate tribasic, sodium carboxymethyl starch, hydroxypropyl cellulose and magnesium stearate) was investigated by differential scanning calorimetry. The compatibility was further corroborated by Raman spectroscopy and isothermal stress testing experiments. These results revealed that ticagrelor has high compatibility with mannitol, calcium phosphate tribasic, sodium carboxymethyl starch, hydroxypropyl cellulose and magnesium stearate.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP12167747-B Calcium phosphate tribasic Calcium phosphate tribasic 12167-74-7 Price
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