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Complexation of Tocotrienol With Gamma-Cyclodextrin Enhances Intestinal Absorption of Tocotrienol in Rats

Saiko Ikeda, Tomono Uchida, Tomio Ichikawa, Takashi Watanabe, Yukiko Uekaji, Daisuke Nakata, Keiji Terao, Tomohiro Yano

Biosci Biotechnol Biochem. 2010;74(7):1452-7.

PMID: 20622447

Abstract:

To determine the bioavailability of tocotrienol complex with gamma-cyclodextrin, the effects of tocotrienol/gamma-cyclodextrin complex on tocotrienol concentration in rat plasma and tissues were studied. Rats were administered by oral gavage an emulsion containing tocotrienol, tocotrienol with gamma-cyclodextrin, or tocotrienol/gamma-cyclodextrin complex. At 3 h after administration, the plasma gamma-tocotrienol concentration of the rats administered tocotrienol/gamma-cyclodextrin complex was higher than that of the rats administered tocotrienol and gamma-cyclodextrin. In order to determine the effect of complexation on tocotrienol absorption, rats were injected with Triton WR1339, which prevents the catabolism of triacylglycerol-rich lipoprotein by lipoprotein lipase, and then administered by oral gavage an emulsion containing tocotrienol, tocotrienol with gamma-cyclodextrin, or tocotrienol/gamma-cyclodextrin complex. The plasma gamma-tocotrienol concentration of the Triton-treated rats administered tocotrienol/gamma-cyclodextrin complex was higher than that of the other Triton-treated rats. These results suggest that complexation of tocotrienol with gamma-cyclodextrin elevates plasma and tissue tocotrienol concentrations by enhancing intestinal absorption.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP17465860-A Gamma Cyclodextrin Gamma Cyclodextrin 17465-86-0 Price
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