Home
Resources
Publications
Compositional Design and Taguchi Optimization of Hardness Properties in Silicone-Based Ocular Lenses

Compositional Design and Taguchi Optimization of Hardness Properties in Silicone-Based Ocular Lenses

Mohammad Hanifeh, Mojgan Zandi, Parvin Shokrollahi, Mohammad Atai, Ebrahim Gafar-Zadeh, Fahimeh Askari

Prog Biomater. 2017 Sep;6(3):67-74.

PMID: 28508183

Abstract:

A multi-component acrylate-based copolymer system especially designed for application as ocular lenses is developed through free-radical, bulk polymerization of a system containing hydroxyethyl methacrylate, methyl methacrylate, triethylene glycol dimethacrylate, dimethyl itaconate, 3-(trimethoxysilyl) propylmethacrylate, Polyhedraloligomeric silsesquioxane-acrylate (POSS-acrylate) and AIBN as an initiator. The progress of the reaction was monitored by Fourier transform infrared spectroscopy (FTIR). The effect of increasing concentration of the components on the hardness of the synthesized lenses was measured by Shore Durometer before and after immersion in PBS solutions. Extraction test method was performed to analyze the biocompatibility of the fabricated lenses. In this research the Taguchi method was employed to achieve the optimal hardness property which plays a critical role in final application of the lens materials. The Taguchi trial for ocular lens hardness was configured in an L16 orthogonal array, by five control factors, each with four level settings. The results showed that 3-(trimethoxysilyl) propyl methacrylate decreases and 2-hydroxyethylmethacrylate increases, polyhedraloligomeric silsesquioxane with a cage-like structure, methyl methacrylate and dimethyl itaconate increase the hardness. Proliferation and growth of the cells showed that there is no toxic substance extracted from the lenses which can interfere with the cell growth.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP4369146	3-(Trimethoxysilyl)propyl acrylate		4369-14-6	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: